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C14144 Saracatinib(AZD0530) (379231-04-6)

Catalog No.:	C14144
CAS No.:	379231-04-6
Synonym:	AZD0530
Chemical Name:	N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Molecular Formula:	C₂₇H₃₂ClN₅O₅
Molecular Weight:	542.03

Technical Data:

Appearance:	Of-white powder
Solubility:	Soluble in DMSO and Methanol
Purity:	>99%
Storage:	at +4℃
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Saracatinib(AZD0530):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

An orally bioavailable tyrosine kinase inhibitor, specifically targeting Src and Abl, those kinases often overexpressed in chronic myeloid leukema cells. Optimal water-soluble form.

References:

1.Green TP, et al. Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Mol Oncol, 2009, 3(3), 248-261.
2. Purnell PR, et al. The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells. J Thorac Oncol, 2009, 4(4), 448-454.

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