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Biological Activity:
Etoposide inhibits the growth of murine angiosarcoma cell line (ISOS-1) in a 5 days-period with IC50 of 0.25 μg/mL. Cell growth of normal murine microvascular endothelial cells (mECs) is less sensitive to Etoposide with IC50 of 10 μg/mL) [1]. Etoposide treated for 6 hr inhibits colonies of tetraploid variant of the human leukemic lymphoblast line CCRF-CEM with IC50 of 0.6 μM [2]. Etoposide administrated as a single agent is found to been ineffective in many xenografts growth, such as Heterotransplanted Hepatoblastoma NMHB1, and NMHB 2 [3].
References:
1.Ma, G., et al., Treatment of murine angiosarcoma with etoposide, TNP-470 and prednisolone. J Dermatol Sci, 2000. 24(2): p. 126-33. 2. Kalwinsky, D.K., et al., Effects of the epipodophyllotoxin VP-16-213 on cell cycle traverse, DNA synthesis, and DNA strand size in cultures of human leukemic lymphoblasts. Cancer Res, 1983. 43(4): p. 1592-7.
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C13652 Etoposide(VP-16) (33419-42-0)