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C13934 Nilotinib(AMN 107) (641571-10-0)

Catalog No.:	C13934
CAS No.:	641571-10-0
Synonym:	AMN-107,Tasigna
Chemical Name:	4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide.
Molecular Formula:	C₂₈H₂₂F₃N₇O
Molecular Weight:	529.52

Technical Data:

Appearance:	White or almost white powder
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	Store at +4°C
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Nilotinib(AMN 107):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

A highly selective inhibitor of Bcr-Abl, the definitive cause of Ph+ CML, and its mutations.

References:

1. Gallipoli P et al. JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood : (2014).

2. Zhang H et al. Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia. PLoS One 9:e100960 (2014).

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