Contact us for competitive discounts on bulk quantities
Biological Activity:
Orally active, subtype-selective partial agonist at α4β2 nicotinic receptors (Ki values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo.
References:
Coe JW et al.Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.J Med Chem48:3474-7 (2005).