ICONHome   ICONContact us   ICONAdd Favorites
Biochemtek
Search Product
Live Chat E-mail
Pharmacology
ICON Inhibitors
ICON Receptors
ICON Hedgehog Signaling Pathway
ICON Stem Cells & Wnt
ICON Signal Transduction
   More +
Research Area
ICON Cancer
ICON Antivirus
ICON Cardiovascular System
ICON Endocrinology
ICON Neuroscience
   More +
Product Type
ICON Natural Products
ICON Peptides
ICON Prostaglandins
ICON Vitamin D series compounds
ICON Toxins
   More +
Browse Alphabetically by Name
ALL A B C D E F
G H I J K L M
N O P Q R S T
U V W X Y Z Others
 
ICONC13260 BIBW 2992(Afatinib) (439081-18-2)
 
 
Catalog No.: C13260
CAS No.: 439081-18-2
Synonym: Afatinib
Chemical Name:

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3''S'')-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide

Molecular Formula:

C24H25ClFN5O3

Molecular Weight: 485.95
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of BIBW 2992(Afatinib):

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Second generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal receptor 2 (Her2 or ErbB 2) and EGFR (HER1) kinases. An investigational drug for breast cancer as well as other EGFR and Her2 driven cancers such as NSCLC and Head-and-Neck

 
References:

1. Solca F  et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther 343:342-50 (2012). 

2. Ioannou N  et al. Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells. Br J Cancer 105:1554-62 (2011).

 
View Related Products by Target:
Nilotinib(AMN 107)
NVP-TAE684-TAE 684
Motesanib(AMG706)
Imatinib mesylate(STI-571)
Dovitinib lactate(TKI258)
Pelitinib(EKB-569)
PF 2341066(Crizotinib)
ABT-869(Linifanib)
BIBF1120(Vargatef)
CHIR-258(Dovitinib,TKI258)
Brivanib alaninate(BMS-582664)
Lapatinib Ditosylate (GW-572016)
 
 

Keywords: Buy BIBW 2992(Afatinib) | BIBW 2992(Afatinib) Supplier | Purchase BIBW 2992(Afatinib) | BIBW 2992(Afatinib) Cost | BIBW 2992(Afatinib)  Manufacturer | Order BIBW 2992(Afatinib) | BIBW 2992(Afatinib) Distributor | BIBW 2992(Afatinib) Structure, Chembest

Buy 439081-18-2| 439081-18-2 Supplier | Purchase 439081-18-2 | 439081-18-2 Cost | 439081-18-2 Manufacturer | Order 439081-18-2 | 439081-18-2 Distributor | 439081-18-2 Structure, Chembest  

Products are for research use only. Not for human use. We do not sell to patients.
Copyright © 2010-2013 Chembest Research Laboratories. All Rights Reserved
E-mail:sales@biochembest.com