ICONHome   ICONContact us   ICONAdd Favorites
Biochemtek
Search Product
Live Chat E-mail
Pharmacology
ICON Inhibitors
ICON Receptors
ICON Hedgehog Signaling Pathway
ICON Stem Cells & Wnt
ICON Signal Transduction
   More +
Research Area
ICON Cancer
ICON Antivirus
ICON Cardiovascular System
ICON Endocrinology
ICON Neuroscience
   More +
Product Type
ICON Natural Products
ICON Peptides
ICON Prostaglandins
ICON Vitamin D series compounds
ICON Toxins
   More +
Browse Alphabetically by Name
ALL A B C D E F
G H I J K L M
N O P Q R S T
U V W X Y Z Others
 
ICONC13991 PD 184352(CI-1040) (212631-79-3)
 
 
Catalog No.: C13991
CAS No.: 212631-79-3
Synonym: CI-1040
Chemical Name:

2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

Molecular Formula:

C17H14ClF2IN2O2

Molecular Weight: 478.66
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: at +4°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of PD 184352(CI-1040):

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

PD184352 is a MEK inhibitor (IC50 = 10-100 nM), a kinase upstream in the mitogen-activated protein kinase pathway (MAPK). Inhibition of MEK leads to a reduction of MAPK activation, suppressing colon tumor proliferation in mice with limited organism toxicity.

 
References:

1. Cossa G  et al. Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells. Cancer Lett 347:212-24 (2014).

2. Allen LF  et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol30:105-16 (2003). 

 
View Related Products by Target:
LY404039(LY2140023)
GDC-0941 bismesylate
Triptolide(PG490)
Pirfenidone
GDC-0449(Vismodegib)
Deforolimus(MK-8669)
Temsirolimus (CCI-779, Torisel)
SL 327
Neratinib(HKI 272)
Sorafenib(Nexavar,Bay43-9006)
Hydroxypropyl-β-cyclodextrin(HPBCD; HPCD)
Elacridar
 
 

Keywords: Buy PD 184352(CI-1040) | PD 184352(CI-1040) Supplier | Purchase PD 184352(CI-1040) | PD 184352(CI-1040) Cost | PD 184352(CI-1040)  Manufacturer | Order PD 184352(CI-1040) | PD 184352(CI-1040) Distributor | PD 184352(CI-1040) Structure, Chembest

Buy 212631-79-3| 212631-79-3 Supplier | Purchase 212631-79-3 | 212631-79-3 Cost | 212631-79-3 Manufacturer | Order 212631-79-3 | 212631-79-3 Distributor | 212631-79-3 Structure, Chembest  

Products are for research use only. Not for human use. We do not sell to patients.
Copyright © 2010-2013 Chembest Research Laboratories. All Rights Reserved
E-mail:sales@biochembest.com