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ICONC13927 Neratinib(HKI 272) (698387-09-6)
 
 
Catalog No.: C13927
CAS No.: 698387-09-6
Synonym: HKI-272; HKI272; HKI 272
Chemical Name:
(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular Formula: C30H29ClN6O3
Molecular Weight: 557.09
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Neratinib(HKI 272):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:

An irreversible tyrosine kinase inhibitor with activity against HER2 and EGFR kinases; a therapeutic agent under investigation for the treatment breast cancer and other solid tumours.

 

 
References:
 Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64(11), 3958-3965.
 
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