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ICONC14336 Voglibose(A 71100) (83480-29-9)
 
 
Catalog No.: C14336
CAS No.: 83480-29-9
Synonym: A 71100
Chemical Name:
5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol
Molecular Formula: C10H21NO7
Molecular Weight: 267.13
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Water
Purity: >98%
Storage: Store at room temperature.
Original QC Data:
Shipping Conditions: Ambient Temp.
 
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Biological Activity:
Orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.
 
References:

1. Jones RB  et al. Effect of linagliptin, alone and in combination with voglibose or exendin-4, on glucose control in male ZDF rats. Eur J Pharmacol 729:59-66 (2014). 

2. Mukherjee A & Sengupta S Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present in Azadirachta indica (neem) useful for the treatment of diabetes. J Enzyme Inhib Med Chem 28:900-10 (2013).

 
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