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ICONC14084 Ramatroban(BAY-U3405) (116649-85-5)
 
 
Catalog No.: C14084
CAS No.: 116649-85-5
Synonym: BAY-U3405
Chemical Name:
3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid
Molecular Formula: C21H21FN2O4S
Molecular Weight: 416.47
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Ramatroban(BAY-U3405):

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Biological Activity:
Dual CRTH2 and potent TXA2 receptor antagonist (Ki values are 4.3 and 4.5 nM at CRTH2 and TXA2 receptors respectively). Reduces antigen-induced inflammatory responses in vivo. Orally active.
 
References:
Suzuki Y  et al. Prophylactic effects of the histamine H1 receptor antagonist epinastine and the dual thromboxane A2 receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells antagonist ramatroban on allergic rhinitis model in mice. Biol Pharm Bull 34:507-10 (2011).
 
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