Buy SB 271046(SB 737050) hydrochloride|209481-20-9|Inhibitors|from supplier chembestbuy.com|Research only

Home

Add Favorites

Search Product

Live Chat

E-mail

Pharmacology

Inhibitors

Receptors

Hedgehog Signaling Pathway

Research Area

Cardiovascular System

Product Type

Vitamin D series compounds

Toxins

　 More +

Browse Alphabetically by Name

ALL	A	B	C	D	E	F
G	H	I	J	K	L	M
N	O	P	Q	R	S	T
U	V	W	X	Y	Z	Others

C14150 SB 271046(SB 737050) hydrochloride (209481-20-9)

Catalog No.:	C14150
CAS No.:	209481-20-9
Synonym:	SB 737050 HCl
Chemical Name:	5-chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
Molecular Formula:	C₂₀H₂₂ClN₃O₃S₂^.HCl
Molecular Weight:	488.45

Technical Data:

Appearance:
Solubility:	Soluble in Water
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of SB 271046(SB 737050) hydrochloride:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Selective, orally active 5-HT₆ antagonist (pK_i values are 9.02-8.92, 6.55, 6.35, 6.27, 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT₆, 5-HT_1D, 5-HT_1A, D₃, 5-HT_1B, 5-HT_1F, α_1B, 5-HT_2C, 5-HT_2A, D₂, 5-HT_2B, 5-HT₇, 5-HT₄ and 5-HT_1E respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. Increases extracellular glutamate and aspartate in the frontal cortex, and exhibits anticonvulsant activity (EC₅₀ = 0.16 μM).

References:

Bromidge et al (1999) 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT₆ receptor antagonist. J.Med.Chem. 42 202. PMID: 9925723.

View Related Products by Target:

Vandetanib(AZD6474)

Vorinostat(SAHA)

Tozasertib(VX-680)

Lenalidomide(CC-5013)

Sunitinib Malate(Sutent)

Keywords: Buy SB 271046(SB 737050) hydrochloride | SB 271046(SB 737050) hydrochloride Supplier | Purchase SB 271046(SB 737050) hydrochloride | SB 271046(SB 737050) hydrochloride Cost | SB 271046(SB 737050) hydrochloride Manufacturer | Order SB 271046(SB 737050) hydrochloride | SB 271046(SB 737050) hydrochloride Distributor | SB 271046(SB 737050) hydrochloride Structure, Chembest