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ICONC13876 Methotrexate((+)-4-Amino-10-methylfolic acid) (59-05-2)
 
 
Catalog No.: C13876
CAS No.: 59-05-2
Synonym: (+)-4-Amino-10-methylfolic acid
Chemical Name:
N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid
Molecular Formula: C20H22N8O5
Molecular Weight: 454.44
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity:
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Methotrexate((+)-4-Amino-10-methylfolic acid):

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Biological Activity:
Potent, competitive dihydrofolate reductase inhibitor (IC50 = 2.6 nM). Induces late S/G2 cell cycle arrest and apoptosis. Antitumor, anti-inflammatory and antirheumatic agent. Active in vitro and in vivo.
 
References:

1. Imwong M  et al. Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax. J Infect Dis203:207-10 (2011).

2. Cronstein BN The mechanism of action of methotrexate. Rheum Dis Clin North Am 23:739-55 (1997).

 
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