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ICONC13532 Dapoxetine hydrochloride (129938-20-1(119356-77-3))
 
 
Catalog No.: C13532
CAS No.: 129938-20-1(119356-77-3)
Synonym: Priligy; LY-210448 hydrochloride
Chemical Name:
(1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride
Molecular Formula: C21H23NO.HCl
Molecular Weight: 341.88
 
Technical Data:
Appearance:
Solubility: Soluble in Water
Purity:
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Dapoxetine hydrochloride:

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Biological Activity:
Potent short-acting SSRI (IC50 = 1.12 nM). Kv4.3 channel blocker (IC50 = 5.3 μM). Centrally active. Inhibits the expulsion reflex of ejaculation in vivo. Orally active.
 
References:

1. Jeong I  et al. Block of cloned Kv4.3 potassium channels by dapoxetine. Neuropharmacology 62:2261-6 (2012).

2. Giuliano F & Clèment P Pharmacology for the treatment of premature ejaculation. Pharmacol Rev 64:621-44 (2012).

 
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