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ICONC14169 SGX-523(SGX 523) (1022150-57-7)
 
 
Catalog No.: C14169
CAS No.: 1022150-57-7
Synonym: SGX 523
Chemical Name:
6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Molecular Formula: C18H13N7S
Molecular Weight: 359.41
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity:
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of SGX-523(SGX 523):

Size

Price

Stock

10mg 

USD150

In Stock 

50mg 

USD380

In Stock 

100mg 

Get quote

 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:
Selective and potent c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma and lung and gastric cancers.
 
References:

Buchanan SG, et al. Mol Cancer Ther, 2009, 8(12), 3181-3190.

 
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