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ICONC13606 Elacridar (143664-11-3)
 
 
Catalog No.: C13606
CAS No.: 143664-11-3
Synonym: GF120918
Chemical Name:
N-[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
Molecular Formula: C34H33N3O5
Molecular Weight: 563.64
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >95%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Elacridar:

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Biological Activity:
Elacridar is a P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor that has been used to improve the brain distribution of drugs that are substrates of P-gp and BCRP. Recent data indicate that they may also be substrates of these multidrug transporters (MDTs).
 
References:

1. Tang SC, et al. Int J Cancer. 2014, 134(6), 1484-1494.

2. Hyafil F, et al. Cancer Res. 1993, 53(1), 4595-4602.

 
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