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ICONC16408 Crizotinib hydrochloride (1415560-69-8)
 
 
Catalog No.: C16408
CAS No.: 1415560-69-8
Synonym: PF-02341066 hydrochloride; PF 02341066 hydrochloride
Chemical Name:
Crizotinib HCl
Molecular Formula: C21H23Cl3FN5O
Molecular Weight: 486.8
 
Technical Data:
Appearance:
Solubility: Soluble in Water
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Crizotinib hydrochloride:

Size

Price

Stock

10mg 

USD

In Stock 

25mg 

USD

In Stock 

50mg 

USD

In Stock 

Contact us for competitive discounts on bulk quantities
 
Biological Activity:

Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma.
 
References:

1. Sparidans RW, Tang SC, Nguyen LN, Schinkel AH, Schellens JH, Beijnen JH.Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor 

crizotinib in mouse plasma.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 15;905:150-4. Epub2012 Aug 21.


2.Crystal AS, Shaw AT.Variants on a Theme: A Biomarker of Crizotinib Response in ALK-Positive Non-Small Cell Lung Cancer?Clin Cancer Res. 2012 Sep 1;18(17):4479-81. Epub 2012 Aug 21.

 
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