ICONHome   ICONContact us   ICONAdd Favorites
Biochemtek
Search Product
Live Chat E-mail
Pharmacology
ICON Inhibitors
ICON Receptors
ICON Hedgehog Signaling Pathway
ICON Stem Cells & Wnt
ICON Signal Transduction
   More +
Research Area
ICON Cancer
ICON Antivirus
ICON Cardiovascular System
ICON Endocrinology
ICON Neuroscience
   More +
Product Type
ICON Natural Products
ICON Peptides
ICON Prostaglandins
ICON Vitamin D series compounds
ICON Toxins
   More +
Browse Alphabetically by Name
ALL A B C D E F
G H I J K L M
N O P Q R S T
U V W X Y Z Others
 
ICONC13417 Cabazitaxel (183133-96-2)
 
 
Catalog No.: C13417
CAS No.: 183133-96-2
Synonym: XRP6258; RPR-116258A; taxoid XRP6258
Chemical Name:
(alpha R,beta S)-beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-Benzenepropanoic acid 2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Molecular Formula: C45H57NO14
Molecular Weight: 835.93
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Cabazitaxel:

Size

Price

Stock

10mg 

USD

In Stock 

25mg 

USD

In Stock 

50mg 

USD

In Stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Cabazitaxel(XRP6258; RPR-116258A) is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

 
References:

1. Figg WD 2nd, Figg WD. Cabazitaxel: filling one of the gaps in the treatment of prostate cancer. Cancer Biol Ther. 2011 Jan 12;10(12):1233-4.

2. Diéras V, Lortholary A, Laurence V et al. Cabazitaxel in patients with advanced solid tumours: Results of a Phase I and pharmacokinetic study. Eur J Cancer. 2012 Sep 10. [Epub ahead of print]

3. Yap TA, Pezaro CJ, de Bono JS. Cabazitaxel in metastatic castration-resistant prostate cancer. Expert Rev Anticancer Ther. 2012 Sep;12(9):1129-36.

 
View Related Products by Target:
Docetaxel Anhydrous
Decitabine(NSC127716)
Topotecan hydrochloride
Leucovorin calcium(Calcium folinate)
XAV-939(NVP-XAV939)
Roscovitine(CYC202)
SN-38(7-Ethyl-10-hydroxycamptothecin)
CPT-11(Irinotecan hydrochloride)
Carboplatin
Cisplatin(CDDP)
ZM 447439
AZD1152-HQPA(Barasertib)
 
 

Keywords: Buy Cabazitaxel | Cabazitaxel Supplier | Purchase Cabazitaxel | Cabazitaxel Cost | Cabazitaxel  Manufacturer | Order Cabazitaxel | Cabazitaxel Distributor | Cabazitaxel Structure, Chembest

Buy 183133-96-2| 183133-96-2 Supplier | Purchase 183133-96-2 | 183133-96-2 Cost | 183133-96-2 Manufacturer | Order 183133-96-2 | 183133-96-2 Distributor | 183133-96-2 Structure, Chembest  

Products are for research use only. Not for human use. We do not sell to patients.
Copyright © 2010-2013 Chembest Research Laboratories. All Rights Reserved
E-mail:sales@biochembest.com