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C13884 Mifamurtide (83461-56-7)

Catalog No.:	C13884
CAS No.:	83461-56-7
Synonym:	CGP 19835A Lipid; muramyl tripeptide phosphatidylethanolamine liposome;Mepact;Junovan;L-MTP-PE
Chemical Name:	2-[[(2S)-2-[[(4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]ethyl 2,3-di(hexadecanoyloxy)propyl phosphoric acid;N-(N-Acetylmuramoyl)-L-alanyl-D-alpha-glutaminyl-N-[(7R)-4-hydroxy-4-oxido-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-trioxa-4-phosphapentacos-1-yl]-L-alaninamide
Molecular Formula:	C₅₉H₁₀₉N₆O₁₉P
Molecular Weight:	1237.50

Technical Data:

Appearance:
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Mifamurtide:

Size	Price	Stock
10mg	USD	In Stock
25mg	USD	In Stock
50mg	USD	In Stock

Biological Activity:

Mifamurtide(CGP19835; MTP-PE) is a drug against osteosarcoma.

Mifamurtide is an immunomodulator with antitumor effects that appear to be mediated via activation of monocytes and macrophages. Mifamurtide is generally well tolerated; adverse events attributed to administration of the drug include chills, fever, headache, nausea, and myalgias. Based on the available data, mifamurtide can be considered for inclusion in treatment protocols for localized osteosarcoma. Mifamurtide has orphan drug status for the treatment of osteosarcoma in the US and EU.

References:

1. Frampton, J.E., Mifamurtide: a review of its use in the treatment of osteosarcoma. Paediatr Drugs, 2010. 12(3): p. 141-53.

2. Mifamurtide: CGP 19835, CGP 19835A, L-MTP-PE, liposomal MTP-PE, MLV 19835A, MTP-PE, muramyltripeptide phosphatidylethanolamine.

Drugs R D, 2008. 9(2): p. 131-5.

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