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C16267 Labetalone hydrochloride (96441-14-4)

Catalog No.:	C16267
CAS No.:	96441-14-4
Synonym:	2-Hydroxy-5-(2-(4-phenylbutan-2-ylamino)acetyl)benzamide hydrochloride;5-{2[(1-methyl-3-phenyl)propyl]amido}ethyl-1-one salicylamide hydrochloride
Chemical Name:	2-Hydroxy-5-(2-(4-phenylbutan-2-ylamino)acetyl)benzamide hydrochloride;5-{2[(1-methyl-3-phenyl)propyl]amido}ethyl-1-one salicylamide hydrochloride
Molecular Formula:	C₁₉H₂₃ClN₂O₃
Molecular Weight:	362.85

Technical Data:

Appearance:	off-white powder
Solubility:	Soluble in Water
Purity:	≥99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Labetalone hydrochloride:

Size	Price	Stock
10mg	USD	In Stock
25mg	USD	In Stock
50mg	USD	In Stock

Biological Activity:

Labetalone hydrochloride combines both selective, competitive, alpha-1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. In man, the ratios of alpha- to beta- blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenous (IV) administration, respectively. The principal physiologic action of labetalol is to competitively block adrenergic stimulation of β-receptors within the myocardium (β1-receptors) and within bronchial and vascular smooth muscle (β2-receptors), and α1-receptors within vascular smooth muscle. This causes a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined α- and β-adrenergic blocking activity.

References:

1. Katzung, Bertram G. (2006). Basic and clinical pharmacology. New York: McGraw-Hill Medical. p. 170. ISBN 0-07-145153-6.

2. Shiohara T, Kano Y (2007). "Lichen planus and lichenoid dermatoses". In Bolognia JL.Dermatology. St. Louis: Mosby. p. 161. ISBN 1-4160-2999-0.

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