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ICONC14338 Vorinostat(SAHA) (149647-78-9)
 
 
Catalog No.: C14338
CAS No.: 149647-78-9
Synonym: Suberoylanilide hydroxamic acid (SAHA);Zolinza
Chemical Name:

Suberanilohydroxamic acid; N-Hyrdroxy-N'-phenyloctanediamide

Molecular Formula:

C14H20N2O3

Molecular Weight: 264.32
 
Technical Data:
Appearance: White to off-white crystal powder
Solubility: Soluble in DMSO and Methanol
Purity: HPLC>99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Vorinostat(SAHA):
Size Price Stock
1g  USD110 In Stock 
2g USD200 In Stock
 5g   USD450  In Stock 
10g USD800   In Stock
25g  USD1500  In Stock

Contact us for competitive discounts on bulk quantities

 
Biological Activity:
Suberoylanilide Hydroxamic Acid (SAHA) is a potent HDAC (histone deacetylase) inhibitor that has been shown to inhibit proliferation and cause cell cycle arrest at G1. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin.
 
References:
1. Mydlo, J.H., et al. 1988. Prostate. 12: 343-355. PMID: 3393496
2. Munster, P.N., et al. 2001. Cancer Res. 61: 8492-8497. PMID: 11731433
3. Sun, P.C., et al. 2010. J. Biomed. Sci. 17: 76. PMID: 20846458

 
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