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C14089 Rapamycin(Sirolimus) (53123-88-9)

Catalog No.:	C14089
CAS No.:	53123-88-9
Synonym:	Sirolimus, AY-22,989, RAPA, Rapamune;LCP-Siro;SILA 9268A
Chemical Name:	23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine;(3S,6R,7E,9R,10R,12R,14S,15E,17E,19-E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,-25, 26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3--[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]--1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-he-xamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacy-clohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Molecular Formula:	C₅₁H₇₉NO₁₃
Molecular Weight:	914.18

Technical Data:

Appearance:	Off-white to yellow crystalline powder
Solubility:	Soluble in DMSO and ethanol
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Rapamycin(Sirolimus):

Size	Price	Stock
500mg	USD220	In stock
1g	USD400	In stock

Biological Activity:

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.

References:

Kuo et al (1992) Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358 70. PMID: 1614535
Huang et al (2003) Rapamycins: mechanism of action and cellular resistance. Cancer Biol.Ther. 2 221. PMID: 12878853.
Kobayashi et al (2007) Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci. 98 726. PMID: 17425689
Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. 7 9. PMID: 21164513.

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