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ICONC13845 LY404039(LY2140023) (635318-11-5)
 
 
Catalog No.: C13845
CAS No.: 635318-11-5
Synonym: LY2140023
Chemical Name:

(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide

Molecular Formula:

C7H9NO6S

Molecular Weight: 235.21
 
Technical Data:
Appearance: White or off-white crystalline powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of LY404039(LY2140023):

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10mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:
LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.
 
References:
1.Seeman P. An agonist at glutamate and dopamine D2 receptors, LY404039. Neuropharmacology. 2013 Mar;66:87-8.
2. Rorick-Kehn LM, Johnson BG, Knitowski KM, In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders. Psychopharmacology (Berl). 2007 Jul;193(1):121-36.
 
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