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ICONC13672 Flavopiridol(Alvocidib) (146426-40-6)
 
 
Catalog No.: C13672
CAS No.: 146426-40-6
Synonym: L868275;HMR-1275
Chemical Name:

2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
Molecular Formula:

C21H20ClNO5
Molecular Weight: 401.84
 
Technical Data:
Appearance: Light yellow solid
Solubility: Soluble in DMSO
Purity: >98%
Storage: at +4℃
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Flavopiridol(Alvocidib):

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Price

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10mg 

USD

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:

Potent inhibitor of cyclin-dependent kinases (CDKs). Induces apoptosis in certain tumor cells. Interacts with multidrug resistance protein 1 (MRP1)
 
References:
1.Senderowicz, Adrian M. Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials Investigational New Drugs (1999), 17(3), 313-320

2. Mahoney E, Lucas DM, Gupta SV, Wagner AJ, Herman SE, Smith LL, Yeh YY, Andritsos L, Jones JA, Flynn JM, Blum KA, Zhang X, Lehman A, Kong H, Gurcan M, Grever MR, Johnson AJ, Byrd JC.ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-73. Epub 2012 Jun 27.
 
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