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ICONC13450 Cediranib(AZD2171) (288383-20-0)
 
 
Catalog No.: C13450
CAS No.: 288383-20-0
Synonym: AZD2171
Chemical Name:

4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline

Molecular Formula:

C25H27FN4O3

Molecular Weight: 450.51
 
Technical Data:
Appearance: Light yellow powder
Solubility: Soluble in Methanol, acetic ester,Dichloromethane, hardly soluble in water
Purity: >99%
Storage: at +4℃
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Cediranib(AZD2171):

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Cediranib (AZD2171) is a once-daily oral tyrosine kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, c-KIT, and platelet-derived growth factor receptors. Phase 1 studies show cediranib to be generally well tolerated as monotherapy at doses of 45 mg/d or less.

 
References:
1. Wedge SR, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res, 2005, 65(10), 4389-4400.
2. Morton CL, et al. Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program. Pediatr Blood Cancer, 2012, 58(4), 566-571.
 
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