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C13399 Brefeldin A (20350-15-6)

Catalog No.:	C13399
CAS No.:	20350-15-6
Synonym:	Ascotoxin; Cyanein
Chemical Name:	1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent [f]oxacyclotridecin-4-one;
Molecular Formula:	C₁₆H₂₄O₄
Molecular Weight:	280.36

Technical Data:

Appearance:	White to off-white crystalline powder
Solubility:	Soluble in DMSO
Purity:	>99%
Storage:	at -20°C
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Brefeldin A:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

References:

1. Alvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1)

2. Colanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9.

3.Tseng CN, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct

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