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ICONC13593 Doxorubicin HCL (25316-40-9)
 
 
Catalog No.: C13593
CAS No.: 25316-40-9
Synonym: Doxorubicin, Adriamycin, 14-Hydroxydaunomycin, NSC-123127, FI-106
Chemical Name:

(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride

Molecular Formula:

C27H29NO11.HCl

Molecular Weight: 579.99
 
Technical Data:
Appearance: Orange red powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: at +4°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Doxorubicin HCL:

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10mg 

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Biological Activity:

Antitumor antibiotic. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Binds covalently to DNA. Inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1. Immunosuppressive. Antineoplastic. Induces apoptosis.

 
References:

1.Lal S  et al. Pharmacogenetics of target genes across doxorubicin disposition pathway: a review. Curr Drug Metab 11:115-28 (2010).

2.Gieseler F  et al. Cytotoxicity of anthracyclines: correlation with cellular uptake, intracellular distribution and DNA binding. Ann Hematol 69 Suppl 1:S13-7 (1994).

 
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