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ICONC12279 Topotecan hydrochloride  (119413-54-6 )
 
 
Catalog No.: C12279
CAS No.: 119413-54-6
Synonym: Nogitecan hydrochloride; Hycamtin;
Chemical Name:

4-Ethyl-4,9-dihydroxy-10-[(dimethylamino)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; 9-Dimethylaminomethyl-10-hydroxycamptothecin hydrochloride salt; Hycamptamine

Molecular Formula:

C23H23N3O5 . HCl

Molecular Weight: 457.91
 
Technical Data:
Appearance: Yellow colored powder
Solubility: Soluble in water
Purity: >99%
Storage: at +4℃
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Topotecan hydrochloride :

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin. Used in chemotherapy of several different cancers.

 
References:

Hendricks CB, Rowinsky EK, Grochow LB, Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. Cancer Res. 1992 Apr 15;52(8):2268-78.

 
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