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ICONC13945 NVP-AUY922  (747412-49-3)
 
 
Catalog No.: C13945
CAS No.: 747412-49-3
Synonym: VER-52296
Chemical Name:

5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide
Molecular Formula:

C26H31N3O5
Molecular Weight: 465.55
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Methanol
Purity: >99%
Storage: at +4℃
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of NVP-AUY922 :

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Biological Activity:

Highly potent and oral inhibitor of heat shock protein 90 (Hsp90) in vitro and in vivo, with IC50=21 nM in Hsp90 FP binding assay; inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
 
References:

1.Lee KH, et al. Cancer Sci, 2011, 102(7), 1388-1395.

2. Okui T, et al. Anticancer Res, 2011, 31(4), 1197-1204.
 
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