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ICONC13900 MK-2206 (1032350-13-2 )
 
 
Catalog No.: C13900
CAS No.: 1032350-13-2
Synonym: MK2206
Chemical Name:
Molecular Formula:

C25H23Cl2N5O

Molecular Weight: 480.39
 
Technical Data:
Appearance: White solid
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of MK-2206:

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

MK-2206, a highly selective non-ATP competitive allosteric Akti, has nM IC50 and broad preclinical antitumor activity.MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. 1 hr treatment of 1 µM MK-2206 abolished Akt phosphorylation in U87MG cells. MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MG cells.MK-2206 is generally well tolerated at doses up to 60 mg QOD with plasma concentrations that portend activity in preclinical models. PK/PD data suggest a substantial and maintained target inhibition at 60 mg

 
References:
1.Yan L, AACR Annual Meeting 2009: Abstract Number: DDT01-1.

2. Hirai H, et al. Mol Cancer Therapy, 2010, 9(7), 1956-1967.

 
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