Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.

1. van Gijssel HE  et al. Cisplatin-DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatin. Mutagenesis 22:49-54 (2007).

2. Mueller S  et al. Cell-cycle progression and response of germ cell tumors to cisplatin in vitro. Int J Oncol29:471-9 (2006).