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C13741 HA14-1 (65673-63-4)

Catalog No.:	C13741
CAS No.:	65673-63-4
Synonym:	HA-14-1; HA 14-1
Chemical Name:	2-Amino-6-bromo-a-cyano-3-(ethoxycarbonyl)-4H-1-benzopy ran-4-acetic acid ethyl ester
Molecular Formula:	C₁₇H₁₇BrN₂O₅
Molecular Weight:	409.23

Technical Data:

Appearance:
Solubility:	Soluble in DMSO and Ethanol
Purity:	>98%
Storage:	Store at -20°C
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of HA14-1:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Cell-permeable inhibitor of Bcl-2 protein (IC₅₀ ~ 9 μM); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.

References:

Nyhan MJ et al. The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells. Br J Cancer 106:711-8 (2012).

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