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ICONC14182 SL 327 (305350-87-2)
 
 
Catalog No.: C14182
CAS No.: 305350-87-2
Synonym: SL 327; SL-327
Chemical Name:

a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromet hyl)benzeneacetonitrile

Molecular Formula:

C16H12F3N3S

Molecular Weight: 335.35
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: Store at +4°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of SL 327:

Size

Price

Stock

10mg 

USD

In stock 

50mg 

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In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

 
References:

1. Wang X  et al. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J Pharmacol Exp Ther 304:172-8 (2003).

2. Scherle PA  et al. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J Biol Chem 275:37086-92 (2000).

 
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Buy 305350-87-2| 305350-87-2 Supplier | Purchase 305350-87-2 | 305350-87-2 Cost | 305350-87-2 Manufacturer | Order 305350-87-2 | 305350-87-2 Distributor | 305350-87-2 Structure, Chembest  

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