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ICONC14342 VX-702 (479543-46-9)
 
 
Catalog No.: C14342
CAS No.: 479543-46-9
Synonym:
Chemical Name:

6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide

Molecular Formula:

C19H12F4N4O2

Molecular Weight: 404.32
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of VX-702:

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Biological Activity:

A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1β and TNFα (IC₅₀ = 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 µM) completely or partially inhibited platelet agonist induced p38 activation (IC₅₀= 4 to 20 nM).

 
References:

1. Goldstein DM  et al. Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem 53:2345-53 (2010).

2. Kuliopulos A  et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost 92:1387-93 (2004).

 
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