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C13319 Ascomycin(FK520) (104987-12-4)

Catalog No.:	C13319
CAS No.:	104987-12-4
Synonym:	Immunomycin; Fk 520; Fr 520; Fr 900520; L 683590
Chemical Name:	(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Molecular Formula:	C43H69NO12
Molecular Weight:	792.01

Technical Data:

Appearance:
Solubility:	Soluble in DMSO and Ethanol
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Ascomycin(FK520):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

A potent immunosuppressant. Inhibits allogenic T-lymphocyte proliferation. An 21-ethyl analog of FK506.

References:

Vázquez-López A et al. Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus. Pharmacol Biochem Behav 84:511-6 (2006).

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