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Biological Activity:
Anacetrapib (MK-0859) is a CETP inhibitor being developed to treat hypercholesterolemia(elevated cholesterol levels) and prevent cardiovascular disease.
References:
1. Ranalletta M, et al. Biochemical characterization of cholesteryl ester transfer protein inhibitors. J Lipid Res. 2010, 51(9), 2739-2752. 2. Tan EY, et al. Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. Drug Metab Dispos. 2010, 38(3), 459-473.