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ICONC13249 ABT-737  (852808-04-9)
 
 
Catalog No.: C13249
CAS No.: 852808-04-9
Synonym: ABT737; ABT 737
Chemical Name:

4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

Molecular Formula:

C42H45ClN6O5S2

Molecular Weight: 813.43
 
Technical Data:
Appearance: Yellow solid
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of ABT-737 :

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:
A selective inhibitor of BCL-2, in small cell lung cancer.
 
References:

1. Yang MC  et al. Bcl2L12 with a BH3-like domain in regulating apoptosis and TMZ-induced autophagy: A prospective combination of ABT-737 and TMZ for treating glioma. Int J Oncol : (2015).

2. Gu D  et al. Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737. PLoS One 9:e103015 (2014).

 
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