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ICONC13251 ABT-888(Veliparib dihydrochloride) (912445-05-7)
 
 
Catalog No.: C13251
CAS No.: 912445-05-7
Synonym: Veliparib dihydrochloride
Chemical Name:

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
Molecular Formula:

C13H16N4O.2(HCl)
Molecular Weight: 317.22
 
Technical Data:
Appearance:
Solubility: Soluble in Water
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of ABT-888(Veliparib dihydrochloride):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:
BPotent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents.
 
References:

Penning TD, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52(2):514-23.
 
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