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ICONC14357 Y-27632 dihydrochloride (129830-38-2)
 
 
Catalog No.: C14357
CAS No.: 129830-38-2
Synonym: (+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride
Chemical Name:

trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride

Molecular Formula:

C14H21N3O.2HCl

Molecular Weight: 320.26
 
Technical Data:
Appearance: White solid
Solubility: Soluble in DMSO and water
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Y-27632 dihydrochloride:
Size Price Stock
50mg USD300 In stock
100mg USD500 In stock
250mg USD950 In stock

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.

 
References:
1. Uehata, M., et al. 1997. Nature. 389: 990-994. PMID: 9353125
2. Itoh, K., et al. 1999. Nat. Med. 5: 221-225. PMID: 9930872
3. Davies, S.P., et al. 2000. Biochem. J. 351: 95-105. PMID: 10998351
4. Narumiya, S., et al. 2000. Meth. Enzymol. 325: 273-284. PMID: 11036610
5. Köksel, O., et al. 2005. Eur. J. Pharmacol. 510: 135-142. PMID: 15740734
6. Fernandes, L., et al. 2006. Eur. J. Pharmacol. 550: 155-161. PMID: 17010334
 
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