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ICONC13510 CX-4945(Silmitasertib) (1009820-21-6)
 
 
Catalog No.: C13510
CAS No.: 1009820-21-6
Synonym: CX 4945
Chemical Name:
5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid
Molecular Formula: C19H12ClN3O2
Molecular Weight: 349.77
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of CX-4945(Silmitasertib):

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10mg 

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50mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:
Potent, selective ATP-competitive CK2 protein kinase inhibitor (IC50 = 1 nM, CK2α). Shows broad spectrum antiproliferative effects. Inhibits human umbilical vein endothelial cell migration, tube formation and HIF-1α in cancer cells. Shows antitumor effects in vivo. Orally active.
 
References:

1. Siddiqui-Jain A  et al. CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy. Mol Cancer Ther11:994-1005 (2012).

2. Lu H  et al. CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer. Neoplasia 16:789-800 (2014).
 
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