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ICONC13557 Dexrazoxane hydrochloride (149003-01-0)
 
 
Catalog No.: C13557
CAS No.: 149003-01-0
Synonym: Dexrazoxane HCL
Chemical Name:
(S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione hydrochloride
Molecular Formula: C11H16N4O4.HCl
Molecular Weight: 304.73
 
Technical Data:
Appearance:
Solubility: Soluble in Water
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Dexrazoxane hydrochloride:

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Biological Activity:
Topoisomerase II inhibitor. Intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters. Reduces ROS° production and activates the PI3K/Akt survival pathway. Cardioprotective effects when co-administered with doxorubicin in vivo.
 
References:

1. Lebrecht D  et al. Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br J Pharmacol 151:771-8 (2007). 

2. Furue H [Topoisomerase inhibitors developing in Japan]. Gan To Kagaku Ryoho 20:42-9 (1993).

 
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