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ICONC13915 Mycophenolate Mofetil (128794-94-5)
 
 
Catalog No.: C13915
CAS No.: 128794-94-5
Synonym: CellCept; RS 61443; TM-MMF; Linfonex
Chemical Name:
6-[(7-Hydroxy-5-methoxy-4-methyl-1-oxo-3H-isobenzofuran-6-yl)]-4-methyl-hex-4-enoic acid 2-morpholinoethyl ester
Molecular Formula: C23H31NO7
Molecular Weight: 433.49
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Mycophenolate Mofetil:

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Biological Activity:
Immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA (a reversible inhibitor of inosine monophosphate dehydrogenase). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.
 
References:

1. Allison AC & Eugui EM Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 47:85-118 (2000).

2. Wang Y  et al. Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus.Gastroenterology : (2014). 

 
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