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CL1044A CPT-11(Irinotecan hydrochloride) (100286-90-6)

Catalog No.:	CL1044A
CAS No.:	100286-90-6
Synonym:	Irinotecan, Camptothecin 11
Chemical Name:	(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-d ioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride
Molecular Formula:	C33H38N4O6.HCl
Molecular Weight:	623.14

Technical Data:

Appearance:	Pale yellow or yellow crystalline powder
Solubility:	Soluble in Water
Purity:	>99%
Storage:	Store at room temperature
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of CPT-11(Irinotecan hydrochloride):

Size	Price	Stock
100 mg	USD 110	In stock
250 mg	USD 188	In stock
500 mg	USD 306	In stock

Biological Activity:

Inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types.

References:

1. Albertsson P et al. Low-dosage metronomic chemotherapy and angiogenesis: topoisomerase inhibitors irinotecan and mitoxantrone stimulate VEGF-A-mediated angiogenesis. APMIS 120:147-56 (2012).

2. Morton CL et al. Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice. Cancer Chemother Pharmacol 56:629-36 (2005).

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