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Pharmacology

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Hedgehog Signaling Pathway

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Cardiovascular System

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Vitamin D series compounds

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C13430 CaCCinh-A01 (407587-33-1)

Catalog No.:	C13430
CAS No.:	407587-33-1
Synonym:	CaCCinh-A01;CaCC(inh)-A01
Chemical Name:	6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Molecular Formula:	C₁₈H₂₁NO₄S
Molecular Weight:	347.43

Technical Data:

Appearance:
Solubility:	Soluble in DMSO and ethanol
Purity:	>98%
Storage:	Store at -20°C
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of CaCCinh-A01:

Size	Price	Stock
50mg	USD360	In Stock
100mg	USD650	In Stock
500mg	Get quote

Biological Activity:

Calcium-activated chloride channel (CaCC) inhibitor (IC₅₀ ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC₅₀ = 2.1 μM, in TMEM16A-expressing FRT cells).

References:

De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758.

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