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CL2601 NVP-BEZ235 (Dactolisib; BEZ235) (915019-65-7)

Catalog No.:	CL2601
CAS No.:	915019-65-7
Synonym:	Dactolisib; BEZ235;
Chemical Name:	2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile
Molecular Formula:	C₃₀H₂₃N₅O
Molecular Weight:	469.55

Technical Data:

Appearance:	White to light yellow powder
Solubility:	Soluble in DMSO and Methanol
Purity:	>99%
Storage:	at +4℃
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of NVP-BEZ235 (Dactolisib; BEZ235):

Size	Price	Stock
250 mg	USD 236	In stock
500 mg	USD 428	In stock
1 g	USD 816	In stock

Biological Activity:

BEZ235 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.

References:

Maira SM, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther, 2008, 7(7), 1851-1863.

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