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ICONCL1031 Bortezomib (179324-69-7)
 
 
Catalog No.: CL1031
CAS No.: 179324-69-7
Synonym: Velcade, MG-341, PS-341
Chemical Name:

[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid; Velcade; DPBA

Molecular Formula:

C19H25BN4O4

Molecular Weight: 384.24
 
Technical Data:
Appearance: White or off-white crystalline powder
Solubility: Soluble in DMSO and Methanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Bortezomib:

Size

Price

Stock

100 mg 

USD 166

In stock 

250 mg 

USD 236

In stock 

500 mg 

USD 388

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

The first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome, which is a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.

 
References:
1. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22.

2. Boccadoro M, et al. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 2005 Jun 1;5(1):18.

 
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