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ICONCL3112 HA14-1 (65673-63-4)
 
 
Catalog No.: CL3112
CAS No.: 65673-63-4
Synonym: HA-14-1; HA 14-1
Chemical Name:

2-Amino-6-bromo-a-cyano-3-(ethoxycarbonyl)-4H-1-benzopy ran-4-acetic acid ethyl ester

Molecular Formula:

C17H17BrN2O5

Molecular Weight: 409.23
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >98%
Storage: Store at -20°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of HA14-1:

Size

Price

Stock

50 mg 

USD 106

In stock 

100 mg 

USD 186

In stock 

250 mg 

USD 336

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Cell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 μM); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.

 
References:
Nyhan MJ  et al. The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells. Br J Cancer 106:711-8 (2012).
 
View Related Products by Target:
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
 
 

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Buy 65673-63-4| 65673-63-4 Supplier | Purchase 65673-63-4 | 65673-63-4 Cost | 65673-63-4 Manufacturer | Order 65673-63-4 | 65673-63-4 Distributor | 65673-63-4 Structure, Chembest  

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