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CL1634 BIBR-796(Doramapimod) (285983-48-4)

Catalog No.:	CL1634
CAS No.:	285983-48-4
Synonym:	BIRB-796 BS, BIRB-0796, BIRB-796
Chemical Name:	1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea
Molecular Formula:	C31H37N5O3
Molecular Weight:	527.67

Technical Data:

Appearance:	Off-white to gray powder
Solubility:	Soluble in DMSO and Ethanol
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of BIBR-796(Doramapimod):

Size	Price	Stock
25 mg	USD 196	In stock
50 mg	USD 366	In stock
100 mg	USD 636	In stock

Biological Activity:

Small molecule inhibitor of p38 mitrogen-activated protein (MAP) kinase (MAPK); more potent than SB 203580 on p38α and p38β MAPKs; potential agent for the treatment of inflammatory diseases.

References:

Pargellis C, et al. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat Struct Biol, 2002, 9(4), 268-272.

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