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ICONC13263 Agomelatine(S20098) (138112-76-2)
 
 
Catalog No.: C13263
CAS No.: 138112-76-2
Synonym: S-20098,Valdoxan
Chemical Name:

N-(2-(7-Methoxynaphth-1-yl)ethyl)acetamide
Molecular Formula:

C15H17NO2
Molecular Weight: 243.30
 
Technical Data:
Appearance: White or almost white powder
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: Store at room temperature.
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Agomelatine(S20098):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:
Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways.
Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant.
 
References:

Ladurelle N  et al. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology (Berl) 221:493-509 (2012).
 
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