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ICONC10560 Cyclopamine(11-Deoxyjervine) (4449-51-8)
 
 
Catalog No.: C10560
CAS No.: 4449-51-8
Synonym: 11-deoxojervine
Chemical Name:

11-Deoxojervine; (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol

Molecular Formula:

C27H41NO2

Molecular Weight: 411.62
 
Technical Data:
Appearance: White crystalline solid
Solubility: Soluble in ethanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Cyclopamine(11-Deoxyjervine):

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Biological Activity:

Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells.

 
References:

Stanton BZ & Peng LF Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst 6:44-54 (2010).
King RW Roughing up Smoothened: chemical modulators of hedgehog signaling. J Biol 1:8 (2002).

 
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(+)-Egenine
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