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ICONC16410 Zotepine (26615-21-4)
 
 
Catalog No.: C16410
CAS No.: 26615-21-4
Synonym: Zotepine
Chemical Name:
 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
Molecular Formula: C18H18ClNOS
Molecular Weight: 331.86
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Zotepine:

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Biological Activity:
5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Also a potent histamine H1 receptor antagonist (IC50 = 8.0 nM). Atypical antipsychotic; exhibits antidepressive and anxiolytic effects in vivo.
 
References:
Herrick-Davis et al (2000) Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 226.
 
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