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ICONC13587 Dovitinib lactate(TKI258) (915769-50-5)
 
 
Catalog No.: C13587
CAS No.: 915769-50-5
Synonym: CHIR-258
Chemical Name:

4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate hydrate (1:1:1)

Molecular Formula:

C21H21FN6O.C3H6O3.H2O

Molecular Weight: 500.53
 
Technical Data:
Appearance: Brown crystal powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Dovitinib lactate(TKI258):

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Dovitinib lactate is the orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

 
References:
1. Trudel S, et al. Blood. 2005, 105(7), 2941-2948.

2. Huynh H, et al. J Hepatol. 2012, 56(3), 595-601.

 
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